Nioxin Cleanser Shampoo 5. Nioxin Cleanser System 5 is specially designed for normal to thin-looking, medium to coarse, natural or chemically-treated hair. It delivers smoothing control to hair while refreshing the scalp and restoring moisture balance. The Cleanser helps to remove follicle-clogging sebum, fatty acids and environmental residues from the scalp skin and hair. Cleanses to provide thicker-looking hair.